22 days in Panama Itinerary

Arguably the most modern of Central American cities, Panama City boasts a shimmering skyline of glass skyscrapers.

Step off the beaten path and head to Iglesia de la Merced and Iglesia de San Francisco de Asis. Shop till you drop at Multicentro Mall and Weil Art Gallery. Step out of Panama City to go to Portobelo and see Scuba & Snorkeling, which is approximately 1h 50 min away. And it doesn't end there: appreciate the extensive heritage of Casco Viejo, contemplate in the serene atmosphere at Iglesia de San José, get engrossed in the history at Museo del Canal Interoceanico de Panama, and explore the ancient world of Panama La Vieja.

To see ratings, reviews, traveler tips, and more tourist information, you can read our Panama City road trip site.

Willemstad, Curacao to Panama City is an approximately 5.5-hour flight. You'll gain 1 hour traveling from Willemstad to Panama City due to the time zone difference. In July, plan for daily highs up to 36°C, and evening lows to 29°C. On the 24th (Wed), you'll have the morning to explore before heading off to Bocas Town.

The colorful and relaxed Bocas Town has a welcoming atmosphere, with the modestly sized urban area showcasing typical Caribbean clapboard houses and home to a mixed community from across the world.

We've included these beaches for you: Wizard Beach and Starfish Beach. Your cultural itinerary includes sights like Smithsonian Tropical Research Institute and Plastic Bottle Village. Step out of Bocas Town to go to Bluff Beach and see Playa Bluff, which is approximately 30 minutes away. There's more to do: shop like a local with Up In The Hill and discover the deep blue sea with a scuba or snorkeling tour.

You can plan Bocas Town trip in no time by asking Inspirock to help create your itinerary.

Getting from Panama City to Bocas Town by flight takes about 2.5 hours. Other options: do a combination of bus and ferry. Expect little chillier weather when traveling from Panama City in July: highs in Bocas Town hover around 30°C, while lows dip to 30°C. On the 28th (Sun), you're off to Boquete.

Now known internationally for its fresh mountain air, year-round pleasant temperatures, and large community of North American expats, Boquete has changed rapidly since the start of the century, changing from a humble mountain town, into a humble mountain surrounded by gated communities and estates.

Eschew the tourist crowds and head to Volcan Baru National Park and Los Cangilones de Gualaca. Get outdoors at River Rafting & Tubing and Los Ladrillos. Next up on the itinerary: relax and rejuvenate at some of the best spas, stop by The Zapadora, and have fun at Boquete Buggies.

To find more things to do, reviews, maps, and tourist information, use the Boquete road trip website.

You can drive from Bocas Town to Boquete in 5 hours. Wrap up your sightseeing on the 1st (Thu) to allow time to drive to Santa Catalina.

Since Santa Catalina became known in the international surfing community in the 1970s, it has done well to maintain its identity as a tucked-away fishing village.

Kick off your visit on the 1st (Thu): meet some fierce fish with a shark diving experience. Get ready for a full day of sightseeing on the next day: see Rancho Estero and then tour the pleasant surroundings at Lagartero Beach.

To find reviews, photos, other places to visit, and tourist information, use the Santa Catalina online tour itinerary builder.

You can drive from Boquete to Santa Catalina in 5.5 hours. Alternatively, you can do a combination of bus and taxi. Wrap up your sightseeing on the 3rd (Sat) early enough to drive to El Valle de Anton.

Surrounded by lush forests and spectacular mountains, El Valle de Anton serves as the perfect spot to enjoy some of Panama's finest natural attractions.

Step off the beaten path and head to Butterfly Haven and Aprovaca (The Orchid Nursery & Conservation Center). Visiting Leading Adventures and Farallon Butterflies will get you outdoors. Explore El Valle de Anton's surroundings by going to San Carlos (Vista Mar Golf Beach & Marina & El Palmar Beach). Spend the 5th (Mon) exploring nature at Gaital National Park. Next up on the itinerary: take an in-depth tour of The Anton Valley Historical and Cultural Museum.

Before you visit El Valle de Anton, use our trip planner to discover what you can do and see there.

Traveling by car from Santa Catalina to El Valle de Anton takes 5 hours. Alternatively, you can do a combination of taxi, flight, and bus; or take a bus. On the 6th (Tue), wrap the sightseeing up by early afternoon so you can drive to Panama City.

Step off the beaten path and head to Bahai Temple and Fishing Charters & Tours. Satisfy your inner culture vulture at El Arco Chato and Cinta Costera. Go for a jaunt from Panama City to Gamboa to see Panama Rainforest Discovery Center about 54 minutes away. Enjoy Panama City some more: test your team's savvy at popular escape rooms, indulge in some personalized pampering at some of the best spas, view the masterpieces at Karavan Gallery, and browse the exhibits of Nina Concept Store.

To see ratings, reviews, other places to visit, and more tourist information, you can read our Panama City sightseeing planning site.

Traveling by car from El Valle de Anton to Panama City takes 2.5 hours. Alternatively, you can take a bus. You'll have a few hours on the 10th (Sat) to wrap things up before traveling home.